When acid poisoning is treated with milk of magnesia, the alkaline action of milk of magnesia neutralizes the effects of acid poisoning.
A synergistic effectis manufactured when two or even more drugs are used in combination to possibly enhance the pharmacological action of the drug or reduce the elimination amount of the drug.
It can be done that obese Grownups, modest young children, and malnourished individuals won't acquire this dosage. It should be dependent on the individual's system pounds.
Acquired tolerance: We've reviewed this previously mentioned. Recurring drug use in a person for years requires a larger sized dose to make precisely the same effect attained with a traditional dose Formerly.
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Posology aims to ensure the Harmless and successful utilization of medication by pinpointing the suitable dosage for every patient, bearing in mind the person’s special properties and needs.
For drugs whose therapeutic index falls in between three and ten, the utility of precision dosing is less apparent, but there's even now important option for benefit. To ascertain suitability of precision dosing in these drugs, it is especially essential that factors apart from therapeutic index on your own are regarded.
Aggressive/reversible antagonism: It is just a phenomenon where by aggressive antagonists compete with agonists for a standard binding internet site on a receptor.
Prolonged-expression use also brings about alterations in other brain chemical check here systems and circuits as well, affecting functions that come with:
That is shown in Fig. four, the place the dose is reduced to fifty %. As was discussed in earlier papers, these significant responses to small changes in drug dose are a typical attribute of your drug outcome and so are not restricted into the dependent state (Peper et al.
Route of administration affects the therapeutic efficacy of a drug. The route of administration typically controls the success of drug formulation.
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Drug Efficacy/Intrinsic exercise: capability to activate or block a receptor: maximum result a drug can deliver regardless of the dose
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